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Complete the 4-Dose Series of PREVENAR® at the 12-Month Visit* - *The 4th dose of Prevnar® is recommended at 12 to 15 months of age. - This Site is Intended for U.S. Health Care Professionals Only. - Please scroll down to see Important Safety Information. Important Safety Information

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Importance of 4 Doses

Why are 4 doses of Prevnar® important for infants?
Significant decline in well-baby visits after 12 months of age

Why are 4 doses of Prevnar® important for infants?

GMC of pneumococcal antibodies
prior to/following 4th dose of Prevnar® 8

Chart - GMC of pneumococcal antibodies prior to/following 4th of Prevnar®

  • GMC=geometric mean concentration.
  • †GMC from blood drawn at 12 to 15 months.8
  • ‡GMC from blood drawn at 13 to 16 months.8
  • Immunization of infants with all 4 doses is important — administration of the 4th dose results in a brisk anamnestic (memory) immune response.8
  • Even though the minimum serum antibody concentration necessary for protection against invasive pneumococcal disease has not been determined for any serotype, a significant increase in serum antibody concentrations was observed following the 4th dose.1,3

The 4-dose series of Prevnar® increased antibody levels
during a high-risk period.8

Click here to view Prescribing Information.

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Less than 2 visits on average in the second year of life11

Significant decline in well-baby visits
after 12 months of age11†

Chart - Significant decline in well-baby visits after 12 months of age*

  • †Extrapolated from well-child visit data (IMS) and U.S. population data.11

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Important Safety Information

In clinical trials (n=18,168), the most frequently reported adverse events included injection site reactions, fever (38ºC/100.4ºF), irritability, drowsiness, restless sleep, decreased appetite, vomiting, diarrhea, and rash.

Risks are associated with all vaccines, including Prevnar®. Hypersensitivity to any vaccine component, including diphtheria toxoid, is a contraindication to its use. Prevnar® does not provide 100% protection against vaccine serotypes or protect against nonvaccine serotypes.

Please see Prescribing Information.

Indication

Prevnar® is indicated for active immunization of infants and toddlers against invasive disease caused by S. pneumoniae due to capsular serotypes included in the vaccine (4, 6B, 9V, 14, 18C, 19F, and 23F). The routine schedule is 2, 4, 6, and 12 to 15 months of age.

The decision to administer Prevnar® should be based primarily on its efficacy in preventing invasive pneumococcal disease. As with any vaccine, Prevnar® may not protect all individuals receiving the vaccine from invasive pneumococcal disease.

Prevnar® is also indicated for active immunization of infants and toddlers against otitis media caused by serotypes included in the vaccine. However, for vaccine serotypes, protection against otitis media is expected to be substantially lower than protection against invasive disease. Additionally, because otitis media is caused by many organisms other than serotypes of S. pneumoniae represented in the vaccine, protection against all causes of otitis media is expected to be low.

This vaccine is not intended to be used for treatment of active infection.